A hydrophobic funnel governs monovalent cation selectivity in the ion channel TRPM5.

ABSTRACT: A key capability of ion channels is the facilitation of selective permeation of certain ionic species across cellular membranes at high rates. Due to their physiological significance, ion channels are of great pharmaceutical interest as drug targets. The polymodal signal-detecting transient receptor potential (TRP) superfamily of ion channels forms a particularly promising group of drug targets. While most members of this family permeate a broad range of cations including Ca²⁺, TRPM4 and TRPM5 are unique due to their strong monovalent selectivity and impermeability for divalent cations. Here, we investigated the mechanistic basis for their unique monovalent selectivity by in silico electrophysiology simulations of TRPM5. Our simulations reveal an unusual mechanism of cation sele

SUBMITTER: Ives CM 

PROVIDER: S-EPMC11480762 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature