Context-dependent structure formation of hairpin motifs in bacteriophage MS2 genomic RNA.

ABSTRACT: Many functions of ribonucleic acid (RNA) rely on its ability to assume specific sequence-structure motifs. Packaging signals found in certain RNA viruses are one such prominent example of functional RNA motifs. These signals are short hairpin loops that interact with coat proteins and drive viral self-assembly. As they are found in different positions along the much longer genomic RNA, the formation of their correct structure occurs as a part of a larger context. Any changes to this context can consequently lead to changes in the structure of the motifs themselves. In fact, previous studies have shown that structure and function of RNA motifs can be highly context sensitive to the flanking sequence surrounding them. However, in what ways different flanking sequences influence the structure

SUBMITTER: Bukina V 

PROVIDER: S-EPMC11480767 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature