Paternal metformin use and risk of congenital malformations in offspring in Norway and Taiwan: population based, cross national cohort study.

ABSTRACT:

Objective

To evaluate the association between paternal metformin use and risk of congenital malformations in offspring.

Design

Population based, cross national cohort study.

Setting

Norway and Taiwan.

Participants

619 389 offspring with paternal data during the period of sperm development (three months before pregnancy) in the Norwegian cohort during 2010-21 and 2 563 812 in the Taiwanese cohort during 2004-18.

Main outcome measures

The primary outcome was any congenital malformation, and the secondary outcome was organ specific malformations, classified according to the European surveillance of congenital anomalies guidelines. Relative risks were estimated with an unadjusted analysis and with analyses restricted to the cohort of men with type 2 diabetes

SUBMITTER: Meng LC 

PROVIDER: S-EPMC11480814 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature