Apathy and effort-based decision-making in Alzheimer's disease and subjective cognitive impairment.

ABSTRACT:

Introduction

Apathy is a significant feature in Alzheimer's disease (AD) and subjective cognitive impairment (SCI), though its mechanisms are not well established.

Methods

An effort-based decision-making (EBDM) framework was applied to investigate apathy in 30 AD patients, 41 SCI participants, and 55 healthy controls (HC). Data were analyzed using a drift-diffusion model (DDM) to uncover latent psychological processes.

Results

SCI participants reported higher apathy than AD patients and HC. However, informant reports of apathy in AD patients were higher than self-reports and indicated significant apathy compared to HC. Both the AD and SCI groups showed reduced sensitivity to effort changes, linked to executive dysfunction in AD and apathy in SCI. Increased resting fun

SUBMITTER: Attaallah B 

PROVIDER: S-EPMC11480904 | biostudies-literature | 2024 Oct-Dec

REPOSITORIES: biostudies-literature