Templated Pluripotent Stem Cell Differentiation via Substratum-Guided Artificial Signaling.

ABSTRACT: The emerging field of synthetic morphogenesis implements synthetic biology tools to investigate the minimal cellular processes sufficient for orchestrating key developmental events. As the field continues to grow, there is a need for new tools that enable scientists to uncover nuances in the molecular mechanisms driving cell fate patterning that emerge during morphogenesis. Here, we present a platform that combines cell engineering with biomaterial design to potentiate artificial signaling in pluripotent stem cells (PSCs). This platform, referred to as PSC-MATRIX, extends the use of programmable biomaterials to PSCs competent to activate morphogen production through orthogonal signaling, giving rise to the opportunity to probe developmental events by initiating morphogenetic programs in a

SUBMITTER: Brien HJ 

PROVIDER: S-EPMC11480943 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature