Molecular determinants of resurgent sodium currents mediated by Navβ4 peptide and A-type FHFs.

ABSTRACT:

Introduction

Resurgent current (I_NaR ) generated by voltage-gated sodium channels (VGSCs) plays an essential role in maintaining high-frequency firing of many neurons and contributes to disease pathophysiology such as epilepsy and painful disorders. Targeting I_NaR may present a highly promising strategy in the treatment of these diseases. Navβ4 and A-type fibroblast growth factor homologous factors (FHFs) have been identified as two classes of important I_NaR mediators; however, their receptor sites in VGSCs remain unknown, which hinders the development of novel agents to effectively target I_NaR .

Methods

Navβ4 and FHF4A can mediate I_NaR generation through the amino acid segment located

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC11480954 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature