Methamphetamine-related working memory difficulties underpinned by reduced frontoparietal responses.

ABSTRACT: Working memory difficulties are common, debilitating, and may pose barriers to recovery for people who use methamphetamine. Yet, little is known regarding the neural dysfunctions accompanying these difficulties. Here, we acquired cross-sectional, functional magnetic resonance imaging while people with problematic methamphetamine-use experience (MA⁺, n = 65) and people without methamphetamine-use experience (MA^-, n = 44) performed a parametric n-back task (0-back through 2-back). Performance on tasks administered outside of the scanner, together with n-back performance, afforded to determine a latent dimension of participants' working memory ability. Behavioural results indicated that MA⁺ participants exhibited lower scores on this dimension compared to MA

SUBMITTER: Roy RJ 

PROVIDER: S-EPMC11480971 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature