Miktoarm Star-polypept(o)ide-Based Polyion Complex Micelles for the Delivery of Large Nucleic Acids.

ABSTRACT: Miktoarm star polymers exhibit a captivating range of physicochemical properties, setting them apart from their linear counterparts. This study devised a synthetic pathway to synthesize cationic miktoarm stars utilizing polypept(o)ides (PeptoMiktoStars), comprising 3 or 6 polysarcosine (pSar) arms (AB_3×100, AB_6×50, overall 300) for shielding and a cross-linkable poly(S-ethylsulfonyl-l-homocysteine) (pHcy(SO₂Et)₂₀) block and a poly(l-lysine) ((pLys)₂₀) block for nucleic acid complexation. Precise control over the DP_n and narrow molecular weight distributions (D̵ ≈ 1.2) were achieved for both structures. Both PeptoMiktoStars efficiently complexed mRNA and pDNA into polyion complex micelles (PICMs). AB

SUBMITTER: Schwiertz D 

PROVIDER: S-EPMC11480978 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature