The relationship between the intestinal microbiome and body mass index in children with cystic fibrosis.

ABSTRACT:

Background

The nutritional status of children with cystic fibrosis (CF), as assessed by their body mass index percentile (BMIp), is a critical determinant of long-term health outcomes. While the intestinal microbiome plays an important role in nutrition, little is known regarding the relationship of the microbiome and BMIp in children with CF.

Methods

Pediatric patients (< 18 years old) with CF and healthy comparison patients (HCs) were enrolled in the study and stool samples obtained. BMIp was categorized as Green Zone (BMIp > 50th), Yellow Zone (BMIp 25th-49th) and Red Zone (BMIp < 25th). Intestinal microbiome assessment was performed via 16S rRNA gene sequencing; microbial richness, diversity, and differential species abundance were assessed.

Results

Stool samples

SUBMITTER: Bernard R 

PROVIDER: S-EPMC11480998 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature