Automated Optimization of a Multistep, Multiphase Continuous Flow Process for Pharmaceutical Synthesis.

ABSTRACT: Flow synthesis is becoming increasingly relevant as a sustainable and safe alternative to traditional batch processes, as reaction conditions that are not usually achievable in batch chemistry can be exploited (for example, higher temperatures and pressures). Telescoped continuous reactions have the potential to reduce waste by decreasing the number of separate unit operations (e.g., crystallization, filtration, washing, and drying), increase safety due to limiting operator interaction with potentially harmful materials that can be reacted in subsequent steps, minimize supply chain disruption, and reduce the need to store large inventories of intermediates as they can be synthesized on demand. Optimization of these flow processes leads to further efficiency when exploring new reactions, as

SUBMITTER: Boyall SL 

PROVIDER: S-EPMC11481092 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature