Creatine Promotes Endometriosis by Inducing Ferroptosis Resistance via Suppression of PrP.

ABSTRACT: Endometriosis, a chronic inflammatory disease, significantly impairs the quality of life of women in their reproductive years; however, its pathogenesis remains poorly understood. The accumulation of retrograde menstruation and recurrent bleeding fosters a high-iron environment in ectopic lesions, triggering ferroptosis in ectopic endometrial stromal cells (EESCs), thereby hindering the establishment of endometriosis. However, abnormal EESCs demonstrate resistance to ferroptosis in high-iron environments, promoting the progression of this disease. Here, novel findings on the accumulation of creatine, derived from endogenous synthesis, in both peritoneal fluid and EESCs of patients with endometriosis are presented. Creatine supplementation reduces cellular iron concentrations, mitigating ox

SUBMITTER: Chen S 

PROVIDER: S-EPMC11481182 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature