Endothelial Cells Mediated by STING Regulate Oligodendrogenesis and Myelination During Brain Development.

ABSTRACT: Oligodendrocyte precursor cells (OPCs) migrate extensively using blood vessels as physical scaffolds in the developing central nervous system. Although the association of OPCs with the vasculature is critical for migration, the regulatory mechanisms important for OPCs proliferative and oligodendrocyte development are unknown. Here, a correlation is demonstrated between the developing vasculature and OPCs response during brain development. Deletion of endothelial stimulator of interferon genes (STING) disrupts angiogenesis by inhibiting farnesyl-diphosphate farnesyltransferase 1 (FDFT1) and thereby reducing cholesterol synthesis. Furthermore, the perturbation of metabolic homeostasis in endothelial cells increases interleukin 17D production which mediates the signal transduction from endoth

SUBMITTER: Wang W 

PROVIDER: S-EPMC11481185 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature