Computed Tomography Imaging Guided Microenvironment-Responsive Ir@WO_3-x Dual-Catalytic Nanoreactor for Selective Radiosensitization.

ABSTRACT: Radiotherapy (RT) is often administered, either alone or in combination with other therapies, for most malignancies. However, the degree of tumor oxygenation, damage to adjacent healthy tissues, and inaccurate guidance remain issues that result in discontinuation or failure of RT. Here, a multifunctional therapeutic platform based on Ir@WO_3-x is developed which simultaneously addresses these critical issues above for precision radiosensitization. Ir@WO_3-x nanoreactors exhibit strong absorption of X-ray, acting as radiosensitizers. Moreover, ultrasmall Ir enzyme-mimic nanocrystals (NCs) are decorated onto the surface of the nanoreactor, where NCs have catalyst-like activity and are sensitive to H₂O₂ in the tumor microenvironment (TME) under near i

SUBMITTER: Song J 

PROVIDER: S-EPMC11481196 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature