Exudate Unidirectional Pump to Promote Glucose Catabolism Triggering Fenton-Like Reaction for Chronic Diabetic Wounds Therapy.

ABSTRACT: The massive accumulation of exudate containing high concentrations of glucose causes wound infection and triggers the release of inflammatory factors, which in turn delays the closure of diabetic wounds. In this study, a Janus membrane is constructed by combining glucose oxidase (GOx) and copper ions (Cu²⁺) for the treatment of diabetic wounds, which is named as Janus@GOx/Cu²⁺. It consists of hydrophobic, transitional, and superhydrophilic layers in a three-layer structure with gradient hydrophilicity for self-pumping properties. The Janus@GOx/Cu²⁺ membrane triggers a series of cascading reactions while pumping out diabetic wound exudates. First, glucose oxidase loaded onto the hydrophilic layer of the Janus@GOx/Cu²⁺ membrane decomposes glucose i

SUBMITTER: Liang Y 

PROVIDER: S-EPMC11481212 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature