Polidocanol inhibits Enterococcus faecalis virulence factors by targeting fsr quorum sensing system.

ABSTRACT:

Background

The wide spread of antimicrobial resistance in Enterococcus faecalis is a critical global concern, leading to increasingly limited treatment options. The fsr quorum sensing (QS) plays a critical role in the pathogenicity of E. faecalis, allowing bacteria to coordinate gene expression and regulate many virulence factors. Therefore, fsr QS of E. faecalis represents a potential therapeutic target that provides an effective strategy to treat antibiotic-resistant infections induced by E. faecalis.

Methods

In this study, distribution of different virulence factors including, gelatinase, protease, cell surface hydrophobicity and biofilm formation in sixty clinical isolates of Enterococcus faecalis was investigated. Sixty-six compounds were tested for their activity again

SUBMITTER: Ashraf D 

PROVIDER: S-EPMC11481293 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature