Androgen blockage impairs proliferation and function of Sertoli cells via Wee1 and Lfng.

ABSTRACT:

Background

Androgens are essential hormones for testicular development and the maintenance of male fertility. Environmental factors, stress, aging, and psychological conditions can disrupt androgen production, impacting the androgen signaling pathway and consequently spermatogenesis. Within the testes, testosterone is produced by Leydig cells and acts on Sertoli cells by activating the androgen receptor (AR), which then translocates to the nucleus to function as a transcription factor. Despite clinical correlations between low testosterone levels and diminished sperm quality, the precise mechanism remains unclear.

Methods

This study explores the hypothesis that reduced androgen levels impair Sertoli cell function by disrupting AR transcriptional regulation. Using an androgen

SUBMITTER: Zhai W 

PROVIDER: S-EPMC11481299 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature