Impact of letrozole co-treatment in an antagonist protocol for IVF/ICSI: a retrospective study.

ABSTRACT:

Objective

The present study aimed to investigate the impact of combined use of letrozole in an antagonist protocol during IVF on live birth outcomes and to assess the safety of letrozole in terms of maternal and neonatal complications.

Methods

This retrospective cohort study included women undergoing IVF/ICSI and fresh embryo transfer (ET) treatment with and without letrozole co-treatment from 2007 to 2021 at Shanghai Ninth People's Hospital (Shanghai, China). The primary outcome was the live birth rate, while the incidences of maternal and neonatal complications were secondary outcomes. Logistic regression models were used to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for the analyzed outcomes. Sensitivity analysis was performed using a propensi

SUBMITTER: Lin J 

PROVIDER: S-EPMC11481315 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature