Characterizing genetic pathways unique to autism spectrum disorder at multiple levels of biological analysis.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by atypical patterns of social functioning and repetitive/restricted behaviors. ASD commonly co-occurs with ADHD and, despite their clinical distinctiveness, the two share considerable genetic overlap. Given their shared genetic liability, it is unclear which genetic pathways increase the likelihood of ASD independently of ADHD.

Methods

We applied Genomic Structural Equation Modeling (SEM) to GWAS summary statistics for ASD and childhood-diagnosed ADHD, decomposing the genetic variance for ASD into that which is unique to ASD (uASD) and that which is shared with ADHD. We computed genetic correlations between uASD and 83 external traits to estimate genetic overlap between uASD and other

SUBMITTER: Schaffer LS 

PROVIDER: S-EPMC11481320 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature