Matrine alkaloids modulating DNA damage repair in chemoresistant non-small cell lung cancer cells.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC) presents a significant challenge in the medical field due to its high incidence and resistance to chemotherapy. Chemoresistance in NSCLC diminishes treatment efficacy and contributes to poor patient outcomes. Matrine alkaloids have shown promise in reversing chemotherapy resistance in NSCLC by targeting DNA repair mechanisms.

Methods

Utilizing molecular dynamics simulations, we explored the interactions between Matrine alkaloids and DNA repair-related proteins to elucidate their impact on NSCLC cells. In vitro experiments involved treating A549/DDP cells with Matrine alkaloids to evaluate their sensitizing effects on lung cancer cells. Additionally, animal model experiments were conducted to validate the therapeutic potential of

SUBMITTER: Wang F 

PROVIDER: S-EPMC11481340 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature