Galectin-3 inhibition reduces fibrotic scarring and promotes functional recovery after spinal cord injury in mice.

ABSTRACT:

Background

In the context of spinal cord injury (SCI), infiltrating macrophages assume prominence as the primary inflammatory cells within the lesion core, where the fibrotic scar is predominantly orchestrated by platelet-derived growth factor receptor beta (PDGFRβ⁺) fibroblasts. Galectin-3, a carbohydrate-binding protein of the lectin family, is notably expressed by infiltrating hematogenous macrophages and mediates cell-cell interactions. Although Galectin-3 has been shown to contribute to the endocytic internalization of PDGFRβ in vitro, its specific role in driving fibrotic scar formation after SCI has not been determined.

Methods

We employed a crush mid-thoracic (T10) SCI mouse model. Galectin-3 inhibition after SCI was achieved through intrathecal injection

SUBMITTER: Shan F 

PROVIDER: S-EPMC11481377 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature