Identification of novel proteins in inflammatory bowel disease based on the gut-brain axis: a multi-omics integrated analysis.

ABSTRACT:

Background

The gut-brain axis has garnered increasing attention, with observational studies suggesting its involvement in the disease activity and progression of inflammatory bowel disease (IBD), but the precise mechanisms remain unclear.

Materials and methods

In this study, we aimed to investigate "novel proteins" underlying IBD in the brain using a comprehensive multi-omics analysis approach. We performed integrated analyses of proteomics and transcriptomics in the human prefrontal cortex (PFC) tissue, coupled with genome-wide association studies (GWAS) of IBD, crohn's disease (CD), and ulcerative colitis (UC). This included performing protein-wide association studies (PWAS), transcriptome-wide association studies (TWAS), Mendelian randomization (MR), and colocalization an

SUBMITTER: Xu Y 

PROVIDER: S-EPMC11481439 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature