ActA-mediated PykF acetylation negatively regulates oxidative stress adaptability of <i>Streptococcus mutans</i>.

ABSTRACT: Dental caries is associated with microbial dysbiosis caused by the excessive proliferation of Streptococcus mutans in dental biofilms, where oxidative stress serves as the major stressor to microbial communities. The adaptability of S. mutans to oxidative stress is a prerequisite for its proliferation and even for exerting its virulence. Protein acetylation is a reversible and conserved regulatory mechanism enabling bacteria to rapidly respond to external environmental stressors. However, the functions of protein acetylation in regulating oxidative stress adaptability of S. mutans are still unknown. Here, we unveil the impact of acetyltransferase ActA-mediated acetylation on regulating the oxidative stress response of S. mutans. actA overexpression increased the

SUBMITTER: Ma Q 

PROVIDER: S-EPMC11481489 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature