A group B streptococcal type VII-secreted LXG toxin mediates interbacterial competition and colonization of the murine female genital tract.

ABSTRACT: Group B Streptococcus (GBS) asymptomatically colonizes the vagina but can opportunistically ascend to the uterus and be transmitted vertically during pregnancy, resulting in neonatal pneumonia, bacteremia, and meningitis. GBS is a leading etiologic agent of neonatal infection and understanding the mechanisms by which GBS persists within the polymicrobial female genital mucosa has the potential to mitigate subsequent transmission and disease. Type VIIb secretion systems (T7SSb) are encoded by Bacillota and often mediate interbacterial competition using LXG toxins that contain conserved N-termini important for secretion and variable C-terminal toxin domains that confer diverse biochemical activities. Our recent work characterized a role for the GBS T7SSb in vaginal colonization and as

SUBMITTER: Job AM 

PROVIDER: S-EPMC11481500 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature