Investigation of Zur-regulated metal transport systems reveals an unexpected role of pyochelin in zinc homeostasis.

ABSTRACT: Limiting the availability of transition metals at infection sites serves as a critical defense mechanism employed by the innate immune system to combat microbial infections. Pseudomonas aeruginosa exhibits a remarkable ability to thrive in zinc-deficient environments, facilitated by intricate cellular responses governed by numerous genes regulated by the zinc-responsive transcription factor Zur. Many of these genes have unknown functions, including those within the predicted PA2911-PA2914 and PA4063-PA4066 operons. A structural bioinformatics investigation revealed that PA2911-PA2914 comprises a TonB-dependent outer membrane receptor and inner membrane ABC-permeases responsible for importing metal-chelating molecules, whereas PA4063-PA4066 contains genes

SUBMITTER: Secli V 

PROVIDER: S-EPMC11481552 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature