Physiological role and complex regulation of O2-reducing enzymes in the obligate anaerobe Clostridioides difficile.
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ABSTRACT: Clostridioides difficile, the major cause of antibiotic-associated diarrhea, is a strict anaerobic, sporulating Firmicutes. However, during its infectious cycle, this anaerobe is exposed to low oxygen (O2) tensions, with a longitudinal decreasing gradient along the gastrointestinal tract and a second lateral gradient with higher O2 tensions in the vicinity of the cells. A plethora of enzymes involved in oxidative stress detoxication has been identified in C. difficile, including four O2-reducing enzymes: two flavodiiron proteins (FdpA and FdpF) and two reverse rubrerythrins (revRbr1 and revRbr2). Here, we investigated the role of the four O2-reducing enzymes in the tolerance to increasing physiological O2 tensions and air
SUBMITTER: Caulat LC
PROVIDER: S-EPMC11481553 | biostudies-literature | 2024 Oct
REPOSITORIES: biostudies-literature
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