Identifying <i>Candida auris</i> transmission in a hospital outbreak investigation using whole-genome sequencing and SNP phylogenetic analysis.

ABSTRACT: Candida auris poses a global public health challenge, causing multiple outbreaks within healthcare facilities. Despite advancements in strain typing for various infectious diseases, a consensus on the genetic relatedness threshold for identifying C. auris transmission in local hospital outbreaks remains elusive. We investigated genetic variations within our local isolate collection using whole-genome-based single nucleotide polymorphism (SNP) phylogenetic analysis. A total of 74 C. auris isolates were subjected to whole-genome sequencing (WGS) and SNP phylogenetic analysis via the QIAGEN CLC Genomics Workbench. Isolates included known related strains from the same patient, strains from different hospitals, strains from our hospital patients with no epidemiologic

SUBMITTER: Mitchell BI 

PROVIDER: S-EPMC11481579 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature