Assessment of cardiovascular risk in patients with ANCA-associated vasculitis: A systematic review and meta-analysis.

ABSTRACT:

Background

Although many chronic inflammatory conditions are linked to elevated cardiovascular risk, the specific extent of this risk in ANCA-associated vasculitis (AAV) remains elusive, largely due to the disease's rarity. Our study sought to clarify the cardiovascular risks and mortality linked to AAV.

Methods

A systematic literature review was conducted across multiple databases from their inception until April 2024 to identify studies comparing cardiovascular outcomes in patients with and without AAV. R Studio's meta package was used to pool risk ratios under the random-effects model, and statistical significance was set at p < 0.05.

Results

Nine observational studies involving 45024 individuals were included in this analysis. Patients with AAV exhibited a signifi

SUBMITTER: Goyal A 

PROVIDER: S-EPMC11481614 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature