Calcineurin promotes adaptation to chronic stress through two distinct mechanisms.

ABSTRACT: Adaptation to environmental stress requires coordination between stress-defense programs and cell cycle progression. The immediate response to many stressors has been well characterized, but how cells survive in challenging environments long term is unknown. Here, we investigate the role of the stress-activated phosphatase calcineurin (CN) in adaptation to chronic CaCl₂ stress in Saccharomyces cerevisiae. We find that prolonged exposure to CaCl₂ impairs mitochondrial function and demonstrate that cells respond to this stressor using two CN-dependent mechanisms-one that requires the downstream transcription factor Crz1 and another that is Crz1 independent. Our data indicate that CN maintains cellular fitness by promoting cell cycle progression and preventing CaC

SUBMITTER: Flynn MJ 

PROVIDER: S-EPMC11481702 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature