Sex differences in prelimbic cortex calcium dynamics during stress and fear learning.

ABSTRACT: In recent years, research has progressively increased the importance of considering sex differences in stress and fear memory studies. Many studies have traditionally focused on male subjects, potentially overlooking critical differences with females. Emerging evidence suggests that males and females can exhibit distinct behavioral and neurophysiological responses to stress and fear conditioning. These differences may be attributable to variations in hormone levels, brain structure, and neural circuitry, particularly in regions such as the prefrontal cortex (PFC). In the present study, we explored sex differences in prelimbic cortex (PL) calcium activity in animals submitted to immobilization stress (IMO), fear conditioning (FC), and fear extinction (FE). While no significant sex differenc

SUBMITTER: Marin-Blasco I 

PROVIDER: S-EPMC11481719 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature