An iron-binding protein of entomopathogenic fungus suppresses the proliferation of host symbiotic bacteria.

ABSTRACT:

Background

Entomopathogenic fungal infection-induced dysbiosis of host microbiota offers a window into understanding the complex interactions between pathogenic fungi and host symbionts. Such insights are critical for enhancing the efficacy of mycoinsecticides. However, the utilization of these interactions in pest control remains largely unexplored.

Results

Here, we found that infection by the host-specialist fungus Metarhizium acridum alters the composition of the symbiotic microbiota and increases the dominance of some bacterial symbionts in locusts. Meanwhile, M. acridum also effectively limits the overgrowth of the predominant bacteria. Comparative transcriptomic screening revealed that the fungus upregulates the production of MaCFEM1, an iron-binding protein, in the pr

SUBMITTER: Li J 

PROVIDER: S-EPMC11481751 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature