Innate cells and STAT1-dependent signals orchestrate vaccine-induced protection against invasive <i>Cryptococcus</i> infection.

ABSTRACT: Fungal pathogens are underappreciated causes of significant morbidity and mortality worldwide. In previous studies, we determined that a heat-killed, Cryptococcus neoformans fbp1-deficient strain (HK-fbp1) is a potent vaccine candidate. We determined that vaccination with HK-fbp1 confers protective immunity against lethal Cryptococcosis in an interferon γ (IFNγ)-dependent manner. In this study, we set out to uncover cellular sources and relevant targets of the protective effects of IFNγ in response to the HK-fbp1 vaccine. We found that early IFNγ production peaks at day 3 and that monocytes and neutrophils are important sources of this cytokine after vaccination. Neutralization of IFNγ at day 3 results in impaired CCR2⁺ monocyte recruitment and reduced differentiation int

SUBMITTER: Wang K 

PROVIDER: S-EPMC11481872 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature