Antibody sequence determinants of viral antigen specificity.

ABSTRACT: Throughout life, humans experience repeated exposure to viral antigens through infection and vaccination, resulting in the generation of diverse, antigen-specific antibody repertoires. A paramount feature of antibodies that enables their critical contributions in counteracting recurrent and novel pathogens, and consequently fostering their utility as valuable targets for therapeutic and vaccine development, is the exquisite specificity displayed against their target antigens. Yet, there is still limited understanding of the determinants of antibody-antigen specificity, particularly as a function of antibody sequence. In recent years, experimental characterization of antibody repertoires has led to novel insights into fundamental properties of antibody sequences but has been largely decoupl

SUBMITTER: Abu-Shmais AA 

PROVIDER: S-EPMC11481873 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature