Lack of CRH Affects the Behavior but Does Not Affect the Formation of Short-Term Memory.

ABSTRACT: Corticotropin-releasing hormone (CRH) is involved in modification of synaptic transmission and affects spatial discrimination learning, i.e., affects the formation of memory in long-term aspect. Therefore, we have focused on CRH effect on short-term memory. We have used stress task avoidance (maze containing three zones: entrance, aversive, and neutral) and compared the behavior and short-term memory in wild-type mice and mice lacking CRH (CRH KO) experiencing one 120-min session of restraint stress. As control, non-stressed animals were used. As expected, the animals that experienced the stress situation tend to spend less time in the zone in which the restraint chamber was present. The animals spent more time in the neutral zone. There were significant differences in number of freezing b

SUBMITTER: Varejkova E 

PROVIDER: S-EPMC11481924 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature