Partial Recovery of Telomere Length After Long-term Virologic Suppression in Persons With HIV-1.

ABSTRACT:

Background

People with HIV-1 (PWH) age differently than the general population. Blood telomere length (BTL) attrition is a surrogate biomarker of immunosenescence and aging in PWH. BTL is reduced immediately after HIV-1 infection and recovers in PWH with long-term virologic suppression, but the extent of this recovery is unknown.

Methods

This prospective 6-year observational study assessed the evolution of BTL in PWH who were virologically suppressed. A cross-sectional analysis additionally compared BTL with age- and sex-matched blood donors and sex-matched persons older than 60 years from a general population cohort. DNA from whole blood was isolated, and relative BTL was determined by monochrome quantitative multiplex polymerase chain reaction assay and expressed as the ra

SUBMITTER: Cadinanos J 

PROVIDER: S-EPMC11482007 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature