Efficient, gigapixel-scale, aberration-free whole slide scanner using angular ptychographic imaging with closed-form solution.

ABSTRACT: Whole slide imaging provides a wide field-of-view (FOV) across cross-sections of biopsy or surgery samples, significantly facilitating pathological analysis and clinical diagnosis. Such high-quality images that enable detailed visualization of cellular and tissue structures are essential for effective patient care and treatment planning. To obtain such high-quality images for pathology applications, there is a need for scanners with high spatial bandwidth products, free from aberrations, and without the requirement for z-scanning. Here we report a whole slide imaging system based on angular ptychographic imaging with a closed-form solution (WSI-APIC), which offers efficient, tens-of-gigapixels, large-FOV, aberration-free imaging. WSI-APIC utilizes oblique incoherent illumination for initia

SUBMITTER: Zhao S 

PROVIDER: S-EPMC11482188 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature