Common anesthetic used in preclinical PET imaging inhibits metabolism of the PET tracer [¹⁸F]3F4AP.

ABSTRACT: Positron emission tomography (PET) imaging studies in laboratory animals are almost always performed under isoflurane anesthesia to ensure that the subject stays still during the image acquisition. Isoflurane is effective, safe, and easy to use, and it is generally assumed to not have an impact on the imaging results. Motivated by marked differences observed in the brain uptake and metabolism of the PET tracer 3-[¹⁸F]fluoro-4-aminopyridine [(¹⁸F]3F4AP) between human and nonhuman primate studies, this study investigates the possible effect of isoflurane on this process. Mice received [¹⁸F]3F4AP injection while awake or under anesthesia and the tracer brain uptake and metabolism was compared between groups. A separate group of mice received the known cytochro

SUBMITTER: Ramos-Torres K 

PROVIDER: S-EPMC11482445 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature