Real-time monitoring of a 3D blood-brain barrier model maturation and integrity with a sensorized microfluidic device.

ABSTRACT: A significant challenge in the treatment of central nervous system (CNS) disorders is represented by the presence of the blood-brain barrier (BBB), a highly selective membrane that regulates molecular transport and restricts the passage of pathogens and therapeutic compounds. Traditional in vivo models are constrained by high costs, lengthy experimental timelines, ethical concerns, and interspecies variations. In vitro models, particularly microfluidic BBB-on-a-chip devices, have been developed to address these limitations. These advanced models aim to more accurately replicate human BBB conditions by incorporating human cells and physiological flow dynamics. In this framework, here we developed an innovative microfluidic system that integrates thin-film electrodes for non-in

SUBMITTER: Ceccarelli MC 

PROVIDER: S-EPMC11482549 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature