Simultaneous Autophagy and Androgen Receptor Inhibition in a Prostate Cancer Xenograft Model.

ABSTRACT:

Objective

Abi, when used in conjunction with prednisone, is an established treatment for advanced PCa. Our goal was to explore the level of autophagy induced by Abi treatment, both alone and in combination with the autophagy inhibitor Chl, in a castrated mouse xenograft model.

Methods

LNCaP cells were injected into the left and right sides of the back of nude mice that had been previously castrated. Mice were divided into four groups and treated daily with intraperitoneal injections of vehicle (control), Abi (10 mg/kg), Abi (10 mg/kg) combined with Chl (10 mg/kg), or Chl (10 mg/kg), and were monitored for periods of 2 and 3 weeks.

Results

A significant reduction in tumor weight was observed in mice treated with the combination therapy, as opposed to those receiving ve

SUBMITTER: Salemi S 

PROVIDER: S-EPMC11482627 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature