Effects of exercise on whole-blood transcriptome profile in children with overweight/obesity.

ABSTRACT:

Background

The current knowledge about the molecular mechanisms underlying the health benefits of exercise is still limited, especially in childhood. We set out to investigate the effects of a 20-week exercise intervention on whole-blood transcriptome profile (RNA-seq) in children with overweight/obesity.

Methods

Twenty-four children (10.21 ± 1.33 years, 46% girls) with overweight/obesity, were randomized to either a 20-week exercise program (intervention group; n = 10), or to a no-exercise control group (n = 14). Whole-blood transcriptome profile was analyzed using RNA-seq by STRT technique with GlobinLock technology.

Results

Following the 20-week exercise intervention program, 161 genes were differentially expressed between the exercise and the control groups among

SUBMITTER: Altmae S 

PROVIDER: S-EPMC11482632 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature