CD103⁺ cDC1 Dendritic Cell Vaccine Therapy for Osteosarcoma Lung Metastases.

ABSTRACT:

Background

We generated a CD103⁺DC vaccine using K7M3 OS cell lysates (cDCV) and investigated its ability to induce regression of primary tumors, established lung metastases, and a systemic immune response.

Methods

A bilateral tumor model was used to assess cDCV therapy efficacy and systemic immunity induction. K7M3 cells were injected into mice bilaterally. Right-sided tumors received PBS (control) or cDCV. Left-sided tumors were untreated. Tumor growth was compared between the vaccine-treated and untreated tumor on the contralateral side and compared to the control group. The immune cell profiles of the tumors, and tumor-draining lymph nodes (TdLNs) and spleen were evaluated. To determine the efficacy of systemic cDCV therapy against esta

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11482638 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature