High-dimensional Biomarker Identification for Scalable and Interpretable Disease Prediction via Machine Learning Models.

ABSTRACT: Omics data generated from high-throughput technologies and clinical features jointly impact many complex human diseases. Identifying key biomarkers and clinical risk factors is essential for understanding disease mechanisms and advancing early disease diagnosis and precision medicine. However, the high-dimensionality and intricate associations between disease outcomes and omics profiles present significant analytical challenges. To address these, we propose an ensemble data-driven biomarker identification tool, Hybrid Feature Screening (HFS), to construct a candidate feature set for downstream advanced machine learning models. The pre-screened candidate features from HFS are further refined using a computationally efficient permutation-based feature importance test, forming the comprehensi

SUBMITTER: Dai Y 

PROVIDER: S-EPMC11482776 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature