Population dynamics of HIV drug resistance during treatment scale-up in Uganda: a population-based longitudinal study.

ABSTRACT:

Background

Clinical studies have reported rising pre-treatment HIV drug resistance during antiretroviral treatment (ART) scale-up in Africa, but representative data are limited. We estimated population-level drug resistance trends during ART expansion in Uganda.

Methods

We analyzed data from the population-based open Rakai Community Cohort Study conducted at agrarian, trading, and fishing communities in southern Uganda between 2012 and 2019. Consenting participants aged 15-49 were HIV tested and completed questionnaires. Persons living with HIV (PLHIV) provided samples for viral load quantification and virus deep-sequencing. Sequence data were used to predict resistance. Population prevalence of class-specific resistance and resistance-conferring substitutions were estimated

SUBMITTER: Martin MA 

PROVIDER: S-EPMC11482865 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature