The polyadenylase PAPI is required for virulence plasmid maintenance in pathogenic bacteria.

ABSTRACT: Many species of pathogenic bacteria harbor critical plasmid-encoded virulence factors, and yet the regulation of plasmid replication is often poorly understood despite playing a critical role in plasmid-encoded gene expression. Human pathogenic Yersinia, including the plague agent Y. pestis and its close relative Y. pseudotuberculosis, require the type III secretion system (T3SS) virulence factor to subvert host defense mechanisms and colonize host tissues. The Yersinia T3SS is encoded on the IncFII plasmid for Y ersinia virulence (pYV). Several layers of gene regulation enables a large increase in expression of Yersinia T3SS genes at mammalian body temperature. Surprisingly, T3SS expression is also controlled at the level of gene dosage. Th

SUBMITTER: Schubert K 

PROVIDER: S-EPMC11482874 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature