Synergistic Role of Amino Acids in Enhancing mTOR Activation Through Lysosome Positioning.

ABSTRACT: Lysosome positioning, or lysosome cellular distribution, is critical for lysosomal functions in response to both extracellular and intracellular cues. Amino acids, as essential nutrients, have been shown to promote lysosome movement toward the cell periphery. Peripheral lysosomes are involved in processes such as lysosomal exocytosis, cell migration, and metabolic signaling-functions that are particularly important for cancer cell motility and growth. However, the specific types of amino acids that regulate lysosome positioning, their underlying mechanisms, and their connection to amino acid-regulated metabolic signaling remain poorly understood. In this study, we developed a high-content imaging system for unbiased, quantitative analysis of lysosome positioning. We examined the 15 amino a

SUBMITTER: Kolaczkowski OM 

PROVIDER: S-EPMC11482915 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature