The invasion pore induced by <i>Toxoplasma gondii</i>.

ABSTRACT: Obligate intracellular parasites invade host cells to survive. Following host cell contact, the apicomplexan Toxoplasma gondii injects proteins required for invasion into the host cell. Here, electrophysiological recordings of host cells acquired at sub-200 ms resolution allowed detection and analysis of a transient increase in host membrane conductance following exposure to Toxoplasma gondii. Transients always preceded invasion but parasites depleted of the moving junction protein RON2 generated transients without invading, ruling out a direct structural role for RON2 in generating the conductance pathway or restricting the diffusion of its components. Time-series analysis developed for transients and applied to the entire transient dataset (910,000 data points) revealed mul

SUBMITTER: Kegawa Y 

PROVIDER: S-EPMC11482919 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature