Cocaine taking and craving produce distinct transcriptional profiles in dopamine neurons.

ABSTRACT: Dopamine (DA) signaling plays an essential role in reward valence attribution and in encoding the reinforcing properties of natural and artificial rewards. The adaptive responses from midbrain dopamine neurons to artificial rewards such as drugs of abuse are therefore important for understanding the development of substance use disorders. Drug-induced changes in gene expression are one such adaptation that can determine the activity of dopamine signaling in projection regions of the brain reward system. One of the major challenges to obtaining this understanding involves the complex cellular makeup of the brain, where each neuron population can be defined by a distinct transcriptional profile. To bridge this gap, we have adapted a virus-based method for labeling and capture of dopamine nuc

SUBMITTER: Pollock TA 

PROVIDER: S-EPMC11482921 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature