Extensive longevity and DNA virus-driven adaptation in nearctic Myotis bats.

ABSTRACT: The genus Myotis is one of the largest clades of bats, and exhibits some of the most extreme variation in lifespans among mammals alongside unique adaptations to viral tolerance and immune defense. To study the evolution of longevity-associated traits and infectious disease, we generated near-complete genome assemblies and cell lines for 8 closely related species of Myotis. Using genome-wide screens of positive selection, analyses of structural variation, and functional experiments in primary cell lines, we identify new patterns of adaptation contributing to longevity, cancer resistance, and viral interactions in bats. We find that Myotis bats have some of the most significant variation in cancer risk across mammals and demonstrate a unique DNA damage response in prima

SUBMITTER: Vazquez JM 

PROVIDER: S-EPMC11482938 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature