Feature Selection Enhances Peptide Binding Predictions for TCR-Specific Interactions.

ABSTRACT: T-cell receptors (TCRs) play a critical role in the immune response by recognizing specific ligand peptides presented by major histocompatibility complex (MHC) molecules. Accurate prediction of peptide binding to TCRs is essential for advancing immunotherapy, vaccine design, and understanding mechanisms of autoimmune disorders. This study presents a novel theoretical method that explores the impact of feature selection techniques on enhancing the predictive accuracy of peptide binding models tailored for specific TCRs. To evaluate the universality of our approach across different TCR systems, we utilized a dataset that includes peptide libraries tested against three distinct murine TCRs. A broad range of physicochemical properties, including amino acid composition, dipeptide composition, a

SUBMITTER: Teimouri H 

PROVIDER: S-EPMC11482946 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature