A preserved neural code for temporal order between memory formation and recall in the human medial temporal lobe.

ABSTRACT: Temporal memory enables us to remember the temporal order of events happening in our life. The human medial temporal lobe (MTL) appears to contain neural representations supporting temporal memory formation, but the cellular mechanisms that preserve temporal order information for recall are largely unknown. Here, we examined whether human MTL neuronal activity represents the temporal position of events during memory formation and recall, using invasive single and multi-unit recordings in human epilepsy patients (n = 19). Participants freely navigated a virtual environment in order to explore and remember locations and temporal positions of objects. During each exploration period, they sequentially encountered two or three different objects, placed in different locations. This allowed us to

SUBMITTER: Khazali MF 

PROVIDER: S-EPMC11482969 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature