Unraveling the Associations Between Voice Pitch and Major Depressive Disorder: A Multisite Genetic Study.

ABSTRACT: Major depressive disorder (MDD) often goes undiagnosed due to the absence of clear biomarkers. We sought to identify voice biomarkers for MDD and separate biomarkers indicative of MDD predisposition from biomarkers reflecting current depressive symptoms. Using a two-stage meta-analytic design to remove confounds, we tested the association between features representing vocal pitch and MDD in a multisite case-control cohort study of Chinese women with recurrent depression. Sixteen features were replicated in an independent cohort, with absolute association coefficients (beta values) from the combined analysis ranging from 0.24 to 1.07, indicating moderate to large effects. The statistical significance of these associations remained robust, with P-values ranging from 7.2 × 10^-6 to

SUBMITTER: Di Y 

PROVIDER: S-EPMC11482971 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature